How cells kill a "killer" messenger

How cells kill a "killer" messenger

Establishing a link between the nonsense-mediated decay pathway and a gene associated with programmed cell death could explain why this pathway is essential in most, but not all, eukaryotes.

How do lymphocytes kill tumor cells?

837 Phase II Study of Docetaxel in Patients with Epithelial Ovarian Carcinoma Refractory to Platinum. John J. Kavanagh. Andrzej P. Kudelka, Cesar Gonzalez de Leon, Damrong Tresukosol. Mary Hord, M. Beth Finnegan, E. Edmund Kim, Datla Varma, Arthur Forman, Paul Cohen, Creighton L. Edwards, Ralph S. Freedman, and Claire F. Verschraegen. 855 Differential Induction of Apoptosis by all-trans-Retinoi...

How Do Cytotoxic Lymphocytes Kill Cancer Cells?

In the past few years, cancer immunotherapy has emerged as a safe and effective alternative for treatment of cancers that do not respond to classical treatments, including those types with high aggressiveness. New immune modulators, such as cytokines, blockers of CTLA-4 (cytotoxic T-lymphocyte-associated protein 4) and PD-1(programmed cell death protein 1)/PD-L1 (programmed death-ligand 1), and...

How Do Lymphocytes Kill Tumor Cells?1

Introduction The combined modalities of chemotherapy, radiotherapy, and surgery have had a significant impact on cancer mortality. Still, nearly 50% of the adult victims of cancer die of their disease as a result of primary or acquired resistance (1 ). The enormously diverse immune system, able to generate specific soluble and cell-mediated responses to as many as lO ligands, has had strong int...

Signaling in leukemia: which messenger to kill?